Carpal tunnel syndrome is the most common entrapment neuropathy of the upper extremities, and it occurs as a result of compression of the median nerve when passing through the carpal tunnel. So far, in the rehabilitation of carpal tunnel syndrome, classical electrostimulation of the median nerve has been commonly used. However, as a newer therapeutic method, high-energy inductive magnetotherapy is also being utilized. This method targets and strongly stimulates nerve cells and muscles, accelerating tissue regeneration processes. The main objective of this research is to determine the differences between the therapeutic effects of classical electrostimulation and high-energy inductive magnetotherapy of the median nerve in the rehabilitation of patients with carpal tunnel syndrome. In this prospective study, 28 participants diagnosed with carpal tunnel syndrome were randomly assigned by the attending physiatrist into two equal groups. The first group was treated with classical electrostimulation, while the second group underwent high-energy inductive magnetotherapy targeting the affected median nerve. Each participant completed a therapy cycle consisting of 15 sessions. All clinical and electrophysiological parameters for both groups were observed and evaluated before and after the therapy cycle. The data collected were statistically analyzed and presented in tables and graphs. Upon completing the therapy cycle, both groups experienced a statistically significant reduction in pain. The group treated with classical electrostimulation showed a more pronounced reduction in pain compared to the group treated with high-energy inductive magnetotherapy. This was attributed to the higher initial pain intensity in the electrostimulation group, which served as a baseline criterion before the start of the therapy cycle. Additionally, it was found that both therapeutic methods were equally effective in improving the sensory conduction velocity of the median nerve. There was no statistically significant difference in the sensory conduction velocity improvements between the two groups at the end of the therapy cycle. Based on the data collected and the results obtained, it can be concluded that there is no significant difference in the therapeutic effectiveness between classical electrostimulation and high-energy inductive magnetotherapy of the median nerve in the rehabilitation of individuals with carpal tunnel syndrome. However, it is noteworthy that both methods demonstrated therapeutic effectiveness across all analyzed parameters except for grip strength, which is of great importance for the return of satisfactory functional status of patients with this condition.